BackDuration: 15 minutes
Aids in the diagnosis and monitoring of rheumatoid arthritis
Clinical significance of test
Anti-cyclic citrullinate peptide antibody is an autoantibody that binds to synthetic cyclic citrullinate polypeptide (CCP). Measurement of CCP antibody has high sensitivity and specificity for rheumatoid arthritis (RA). CCP antibody is also an early diagnostic indicator to distinguish between invasive and non-invasive RA. Combined detection of Rheumatoid Factor (RF) and CCP antibodies will significantly improve the sensitivity of the diagnosis.
Steps of operation
Clinical application
- Diagnosing rheumatoid arthritis: In people with symptoms, CCP antibody testing is used to help diagnose or rule out rheumatoid arthritis. As there is no single test that can diagnose rheumatoid arthritis, CCP antibody testing is considered in conjunction with other factors, including a patient’s symptoms and the results of other tests.
- Estimating disease severity: CCP testing can help doctors predict the progression of a patient’s rheumatoid arthritis. Patients with early rheumatoid arthritis who test positive for CCP antibodies are at an increased risk of worsening joint damage
Interpretation of results
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